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KMID : 0357119920140020221
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Korean Journal of Immunology
1992 Volume.14 No. 2 p.221 ~ p.230
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Changes of Natural Killer Cell Cytotoxicity after Treatment with Prednisolone and Interferon-α of Chronic Active Hepatitis B
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신전수
최인홍/이관식/한광협/김세종
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Abstract
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Chronic active hepatitis B(CAH) is a common and progressive liver disease for which there is no acceptied therapy, but the administration of corticosteroid followed by interferon(IFN)-αfor a short period might improve clinical symptoms. However,
the
mechanisms how the combined administration of prednisolone with IFN-α brought a clinical improvement have not been elucidated. The purpose of this study is to determine the changes of natural kinller (NK) cells cytotoxicity during the
administration of
prednisolone followfed by IFN-α. The NK cell activities were measured in a total of 10 patients by 4 hour chromium release asay using k562 as target cells, the mean of NK cells activities was lowest just immediately after prednisolone withdrawal
and
highest at 4 weeks after prednisolone withdrawal9just before IFN-α treatment).The changes of mean ALT levels in CAH patients were almost similar to the changes of mean NK ells activities. The changes of mean HBe Ag levels sera were inverse to
the
changes of mean NK cells activities before the initiation of IFN-αtherapy, but declined slowly after IFN-αtreatment except 2 patients. These results suggest that the administration of prednisolone might cause the release of replicated hepatitis
B
viral antigen out of cells and minimize the destruction of hepatocytes, and the increased activity of NK cells and the administration of IFN-α might take a role of antiviral activity.
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KEYWORD
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